What we’re reading.

See what the Herophilus team is reading this week across the fields of neuroscience, organoids, drug discovery, machine learning, bioassays, disease models and more.

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18 November 2022 Molecular Psychiatry

Samudyata, Ana O. Oliveira, Susmita Malwade, Nuno Rufino de Sousa, Sravan K. Goparaju, Jessica Gracias, Funda Orhan, Laura Steponaviciute, Martin Schalling, Steven D. Sheridan, Roy H. Perlis, Antonio G. Rothfuchs & Carl M. Sellgren

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

7 November 2022 nature

Michael J. Gandal, Jillian R. Haney, Brie Wamsley, Chloe X. Yap, Sepideh Parhami, Prashant S. Emani, Nathan Chang, George T. Chen, Gil D. Hoftman, Diego de Alba, Gokul Ramaswami, Christopher L. Hartl, Arjun Bhattacharya, Chongyuan Luo, Ting Jin, Daifeng Wang, Riki Kawaguchi, Diana Quintero, Jing Ou, Ye Emily Wu, Neelroop N. Parikshak, Vivek Swarup, T. Grant Belgard, Mark Gerstein, Bogdan Pasaniuc & Daniel H. Geschwind

Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD

7 November 2022 cell

Bilal Cakir, Ferdi Ridvan Kiral, and In-Hyun Park

Advanced in vitro models: Microglia in action

7 November 2022 nature

Kun Leng, Indigo V. L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero-Fernandez, Brendan Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, Michael V. Sofroniew, Stephen P. J. Fancy, Matthew S. Schrag, Ethan S. Lippmann & Martin Kampmann

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

24 October 2022 nature

Carina Seah, Michael S. Breen, Tom Rusielewicz, Heather N. Bader, Changxin Xu, Christopher J. Hunter, Barry McCarthy, P. J. Michael Deans, Mitali Chattopadhyay, Jordan Goldberg, Frank Desarnaud, Iouri Makotkine, Janine D. Flory, Linda M. Bierer, Migle Staniskyte, NYSCF Global Stem Cell Array® Team, Scott A. Noggle, Laura M. Huckins, Daniel Paull, Kristen J. Brennand & Rachel Yehuda

Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression

24 October 2022 nature

Sara Reardon

Human brain cells implanted in rats prompt excitement — and concern

12 October 2022 nature

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

12 October 2022 nature

Jonas Simon Fleck, Sophie Martina Johanna Jansen, Damian Wollny, Fides Zenk, Makiko Seimiya, Akanksha Jain, Ryoko Okamoto, Malgorzata Santel, Zhisong He, J. Gray Camp & Barbara Treutlein

Inferring and perturbing cell fate regulomes in human brain organoids

3 October 2022 Cell

Ana Uzquiano, Amanda J. Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z. Levin, Paola Arlotta

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex

3 October 2022 Nature

Sergiu P. Pașca, Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, Arnold R. Kriegstein, Madeline A. Lancaster, Guo-Li Ming, Alysson R. Muotri, In-Hyun Park, Orly Reiner, Hongjun Song, Lorenz Studer, Sally Temple, Giuseppe Testa, Barbara Treutlein & Flora M. Vaccarino

A nomenclature consensus for nervous system organoids and assembloids