What we’re reading.

22 August 2022 Nature

Wanze Chen, Orane Guillaume-Gentil, Pernille Yde Rainer, Christoph G. Gäbelein, Wouter Saelens, Vincent Gardeux, Amanda Klaeger, Riccardo Dainese, Magda Zachara, Tomaso Zambelli, Julia A. Vorholt & Bart Deplancke

Live-seq enables temporal transcriptomic recording of single cells

22 August 2022 Science

Yonatan A. Cooper, Noam Teyssier, Nina M. Dräger, Qiuyu Guo, Jessica E. Davis, Sydney M. Sattler, Zhongan Yang, Abdulsamie Patel, Sarah Wu, Sriram Kosuri, Giovanni Coppola, Martin Kampmann & Daniel H. Geschwind

Functional regulatory variants implicate distinct transcriptional networks in dementia

22 August 2022 Current Opinion in Neurobiology

Zhijian Zhang, Richard O'Laughlin, Hongjun Song & Guo-li Ming

Patterning of brain organoids derived from human pluripotent stem cells

11 August 2022 nature

Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan & Martin Kampmann

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

10 August 2022 nature

Jeffrey A. Stogsdill, Kwanho Kim, Loïc Binan, Samouil L. Farhi, Joshua Z. Levin & Paola Arlotta

Pyramidal neuron subtype diversity governs microglia states in the neocortex

9 August 2022 Cell

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

3 August 2022 Nature

Tal Sharf, Tjitse van der Molen, Stella M. K. Glasauer, Elmer Guzman, Alessio P. Buccino, Gabriel Luna, Zhuowei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan, Kenneth R. Tovar, Linda R. Petzold, Andreas Hierlemann, Paul K. Hansma & Kenneth S. Kosik

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

28 July 2022 nature

Hirofumi Kobayashi, Keith C. Cheveralls, Manuel D. Leonetti & Loic A. Royer

Self-supervised deep learning encodes high-resolution features of protein subcellular localization

26 July 2022 nature

Bjarni V. Halldorsson, Hannes P. Eggertsson, Kristjan H. S. Moore, Hannes Hauswedell, Ogmundur Eiriksson, Magnus O. Ulfarsson, Gunnar Palsson, Marteinn T. Hardarson, Asmundur Oddsson, Brynjar O. Jensson, Snaedis Kristmundsdottir, Brynja D. Sigurpalsdottir, Olafur A. Stefansson, Doruk Beyter, Guillaume Holley, Vinicius Tragante, Arnaldur Gylfason, Pall I. Olason, Florian Zink, Margret Asgeirsdottir, Sverrir T. Sverrisson, Brynjar Sigurdsson, Sigurjon A. Gudjonsson, Gunnar T. Sigurdsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Kristjan Norland, Unnur Styrkarsdottir, Droplaug N. Magnusdottir, Steinunn Snorradottir, Kari Kristinsson, Emilia Sobech, Helgi Jonsson, Arni J. Geirsson, Isleifur Olafsson, Palmi Jonsson, Ole Birger Pedersen, Christian Erikstrup, Søren Brunak, Sisse Rye Ostrowski, DBDS Genetic Consortium, Gudmar Thorleifsson, Frosti Jonsson, Pall Melsted, Ingileif Jonsdottir, Thorunn Rafnar, Hilma Holm, Hreinn Stefansson, Jona Saemundsdottir, Daniel F. Gudbjartsson, Olafur T. Magnusson, Gisli Masson, Unnur Thorsteinsdottir, Agnar Helgason, Hakon Jonsson, Patrick Sulem & Kari Stefansson

The sequences of 150,119 genomes in the UK Biobank

8 July 2022 eLife

Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, and Michael D Cahalan

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia