What we’re reading.

See what the Herophilus team is reading this week across the fields of neuroscience, organoids, transcriptomics, machine learning and more.

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28 April 2022 Cell Stem Cell

Mariko L. Bennett, Hongjun Song, Guo-li Ming

Microglia modulate neurodevelopment in human neuroimmune organoids

28 April 2022 Cell Stem Cell

Galina Popova, Sarah S. Soliman, Chang N. Kim, Matthew G. Keefe, Kelsey M. Hennick, Samhita Jain, Tao Li, Dario Tejera, David Shin, Bryant B. Chhun, Christopher S. McGinnis, Matthew Speir, Zev J. Gartner, Shalin B. Mehta, Maximilian Haeussler, Keith B. Hengen, Richard R. Ransohoff, Xianhua Piao, Tomasz J. Nowakowski

Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids

27 April 2022 Neuron

Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Macé, Botond Roska

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

25 April 2022 bioRxiv

Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Alejandro López-Tobón, Erika Tenderini, Flavia Troglio, Michele Gabriele, Raul Bardini Bressan, Steven M Pollard, William T Gibson, Giuseppe Testa

Benchmarking brain organoid recapitulation of fetal corticogenesis

18 April 2022 Nature

Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo & Li Gan

What we’re reading.

Microglia modulate neurodevelopment in human neuroimmune organoids

Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

Benchmarking brain organoid recapitulation of fetal corticogenesis

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

What’s next for AlphaFold and the AI protein-folding revolution

A complete reference genome improves analysis of human genetic variation

Parallel inference of hierarchical latent dynamics in two-photon calcium imaging of neuronal populations

Reproducible brain-wide association studies require thousands of individuals

Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome