What we’re reading.

See what the Herophilus team is reading this week across the fields of neuroscience, organoids, drug discovery, machine learning, bioassays, disease models and more.

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31 January 2023 glia

Yuanyuan Wang, Roxanne V. Kyauk, Yun-An A. Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J. Greene, Morgan Sheng, Tracy J. Yuen

TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection

31 January 2023 Neuron

Kristin S. Levine, Hampton L. Leonard, Cornelis Blauwendraat, Hirotaka Iwaki, Nicholas Johnson, Sara Bandres-Ciga, Luigi Ferrucci, Faraz Faghri, Andrew B. Singleton, Mike A. Nalls

Virus exposure and neurodegenerative disease risk across national biobanks

23 January 2023 biorxiv

Morgan M. Stanton, Sara Modan, Patrick M. Taylor, Harsh N. Hariani, Jordan Sorokin, Brian G. Rash, Sneha B. Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O'Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M. Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia Bardehle, Stefka Gyoneva, Kevan Shah, Saul Kato, Gaia Skibinski

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

23 January 2023 nature

Sergei Grebenyuk, Abdel Rahman Abdel Fattah, Manoj Kumar, Burak Toprakhisar, Gregorius Rustandi, Anja Vananroye, Idris Salmon, Catherine Verfaillie, Mark Grillo & Adrian Ranga

Large-scale perfused tissues via synthetic 3D soft microfluidics

23 January 2023 cell

Zaida Álvarez, J. Alberto Ortega, Kohei Sato, Ivan R. Sasselli, Alexandra N. Kolberg-Edelbrock, Ruomeng Qiu, Kelly A. Marshall, Thao Phuong Nguyen, Cara S. Smith, Katharina A. Quinlan, Vasileios Papakis, Zois Syrgiannis, Nicholas A. Sather, Chiara Musumeci, Elisabeth Engel, Samuel I. Stupp, Evangelos Kiskinis

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

10 January 2023 nature

Joana B. Pereira, Shorena Janelidze, Olof Strandberg, Christopher D. Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren & Oskar Hansson

Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology

10 January 2023 nature

Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Alejandro López-Tobón, Erika Tenderini, Sara Sebastiani, Flavia Troglio, Michele Gabriele, Raul Bardini Bressan, Steven M. Pollard, William T. Gibson & Giuseppe Testa

What we’re reading.

TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection

Virus exposure and neurodegenerative disease risk across national biobanks

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Large-scale perfused tissues via synthetic 3D soft microfluidics

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology

Benchmarking brain organoid recapitulation of fetal corticogenesis

Synaptic degeneration in Alzheimer disease

Microglia-containing human brain organoids for the study of brain development and pathology

Spatially resolved proteomics via tissue expansion