Reading

What we’re reading.

See what the Herophilus team is reading this week across the fields of neuroscience, organoids, drug discovery, machine learning, bioassays, disease models and more.

15 May 2023 Nature
Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, Nelson David Villalba-Moreno, David Aguillon, Ana Baena, Justin S. Sanchez, Clara Vila-Castelar, Liliana Ramirez Gomez, Natalia Chmielewska, Gabriel M. Oliveira, Jessica Lisa Littau, Kristin Hartmann, Kyungeun Park, Susanne Krasemann, Markus Glatzel, Dorothee Schoemaker, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Said Arevalo-Alquichire, Kahira L. Saez-Torres, Dhanesh Amarnani, Leo A. Kim, …Yakeel T. Quiroz

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

7 April 2023 Nature Communications
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski & George M. Church

Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder

23 January 2023 biorxiv
Morgan M. Stanton, Sara Modan, Patrick M. Taylor, Harsh N. Hariani, Jordan Sorokin, Brian G. Rash, Sneha B. Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O'Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M. Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia Bardehle, Stefka Gyoneva, Kevan Shah, Saul Kato, Gaia Skibinski

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes